Dueling Activities of AIF in Cell Death versus Survival DNA Binding and Redox Activity

نویسندگان

  • Stuart A. Lipton
  • Ella Bossy-Wetzel
چکیده

Apoptosis-inducing factor (AIF) was originally discovered as a mitochondrial protein that, like cytochrome c, is released into the cytoplasm during cell death. New evidence suggests, however, that a redox-active enzymatic region of AIF may be antiapoptotic while a DNA binding region is proapoptotic.

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عنوان ژورنال:
  • Cell

دوره 111  شماره 

صفحات  -

تاریخ انتشار 2002